ROLE OF PPARs IN INFLAMMATION, ATHEROSCLEROSIS, AND THROMBOSIS

Peroxisome proliferator-activated receptors (PPARs) are a subfamily of nuclear receptors comprising 3 isotypes, PPARα, β/δ, and γ, which control a variety of cellular functions such as lipid and lipoprotein metabolism, fatty acid oxidation, glucose metabolism, adipogenesis, and cellular differentiation. Moreover, emerging data suggest that, besides their role in regulating metabolic risk factors for cardiovascular diseases, PPARs are involved in the control of vascular inflammation and thrombogenicity related to atherosclerosis. This review will focus on recent developments on the role of PPARα and γ in this field.