Association between DNA-repair gene and glutathione S-transferase gene polymorphisms and clinical outcome in patients (pt) with localized non-small cell lung cancer (NSCLC) treated with sequential radiochemotherapy.

7008 Background: To evaluate the impact of DNA-repair and glutathione S-transferase gene polymorphisms on clinical outcome measured by progression-free (PFS) and overall survival (OS) in patients with localized non-small-cell lung cancer (NSCLC). Methods: DNA for genotyping was extracted from archived paraffin embedded formalin-fixed tumor tissues. Genotyping was performed using PCR-based methods. Genomic polymorphisms of ERCC1, XRCC1, XRCC2, XPA, GSTP1, GSTT1 and GSTM1 were analyzed using PCR-based methods. Results: 116 pt with NSCLC Ib-IIIb 85% received cisplatin-based chemotherapy (cx) prior to radiation. Pt demographics: median age 63 years; ECOG 0/1 and 2: 90%, 10%; 87% male/13% female; 90% of pt got local treatment (radiation and/or resection) following cx. Responses: 72 pt (62%) complete or partial remission, 32 pt (27%) stable disease and 14 pt (11%) progressive disease (PD). Median follow up time was 23.1 months (mo). Relapse or PD was observed in 80% of cases. Median OS of all pt was 23.4 mo and...