Amendatory Effect of Flavonoids in Alzheimer's Disease Against Mitochondrial Dysfuntion.

Flavonoids are chromene analogues abundantly found in plants. It is always of curiosity to discover natural flavonoid structures, since living things, including human, are routinely exposed to these compounds through many dietaries. Indeed, numerous studies conducted so far on flavonoids to display their diverse biological actions. The activity results obtained particularly on the effects of flavonoids on various validated and non-validated targets of Alzheimer's Disease (AD) make these compounds as promising agents either to be directly employed in clinical trials or to be utilized as important scaffolds for flavonoid based drug design studies. Although there are many review articles on the treatment and protective effects of flavonoids on AD, within this review, the effects of flavonoids on mitochondrial dysfunction developing throughout AD have been presented concomitant to their structural organization.