Survivin in ovary tumors.
2015
Objectives
Introduction: Survivin is a member of the inhibitor of apoptosis protein (IAP) family, which are selectively
overexpressed in human neoplasms, and its expression has been shown to be connected with cell proliferation.
We analyzed survivin expression in ovarian epithelial neoplasms to evaluate its role in the development of ovarian
tumors.
Material and methods: Immunohistochemistry assays were conducted in 137 cases (48 ovarian carcinoma,
43 borderline ovarian carcinoma, 46 benign ovarian tumor, and 20 samples of normal ovarian tissue of ovarian
epithelial neoplasms. Histological types included serous (n=68) and mucinous (n=69) tumors. All tumors were
reviewed histopathologically and classified according to the WHO criteria.
Results: Survivin expression in the group of serous neoplasms was detected in 24.0% (6 of 25) of benign cases,
in 60.0% (12 of 20) of borderline tumors, and 91.0% (24 of 47) of ovarian carcinomas. In the group of mucinous
tumors, survivin expression was found in 33.5% (7 of 21) of benign cases, 43.5% (10 of 23) of borderline tumors,
and 80.0% (20 of 25) of malignant tumors.
Conclusions: Our results demonstrate that survivin overexpression may play a crucial role in the development
of epithelial ovarian neoplasms and be an important prognostic factor for the influence of survivin expression on
epithelial ovarian cancers.
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