Indole derivatives and their use as kinase inhibitors, in particular IKK2.

A compound of formula (I) ** ** see formula wherein R1 represents H, halogen, or a group -YZ Y represents a bond (ie is absent it), C 1-6 alkylene or alkenylene C 06.02 ; Z represents an aryl or heteroaryl group each comprising 5-14 ring members, said aryl or heteroaryl being optionally substituted by one or more substituents independently selected from halogen, OH, C 1-6 alkyl, halo C 1-6, C 1-6 alkoxy, haloC 1-6, CN, C 1-6 hydroxyalkyl, phenyl, O- (CH 2) 1-6 phenyl, NHSO 2 R 3, NHCOR 3, CONR 4 R 5, SO 2NR 4 R 5; R 3, R 4 and R 5 independently represent H or C1-6 alkyl; R2 represents H, halogen, or Z 1 And one group; Y 1 represents a bond (ie is absent), C1-6 alkylene, C2-6 alkenylene; Z 1 represents a 6 membered aryl, 5- or 6-membered, 5-7 membered heterocyclyl, C 5-7 cycloalkyl, C 5-7 cycloalkenyl, each of which may be optionally substituted by one or more substituents are independently selected from SO2R 6, NHSO2R 6 ** ** see formula COR 7, NR 7 R 8, SO 2 NR 7 R 8, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy , halogen, CONR 7 R 8, NHCOR 7, or phenyl (directly attached or attached through a spacer C1-6alkylene, CONH, C2-6 alkenylene optionally substituted by one or more substituents selected from C 1 alkyl -6, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, OH, halogen); R 6 represents H, C1-6 alkyl, - (CH2) n phenyl or - (CH2) n napthyl (where n is 0 or 1 and each of said phenyl or naphthyl may be optionally substituted by one or more substituents selected independently from C 1-6 alkyl, C 1-6 alkoxy, halogen, NR 7 R 8, C 1-6 haloalkyl, C 1-6 haloalkoxy), CN or - (O) p phenyl (where p is 0 or 1 and the phenyl is optionally substituted by one or more substituents independently selected from halogen, C1-6 alkyl or C1-6 alkoxy)): R 7 and R 8 independently represent a C 1-6 alkyl, H, alkylene C 1-6 NR 9 R 10; R 9 and R 10 independently represent a C1-6, alkyl H; with the proviso that R 1 and R 2 do not both represent H; or a salt thereof.