Retarded corneoscleral wound healing associated with high preoperative doses of systemic steroids in glaucoma surgery.

: We compared two groups of human eyes with corneoscleral wounds. One group consisted of 100 phakic myopic eyes which received an iris fixated "claw" intraocular lens with a minus power optic. Prior to the operation, 350 mg of prednisone was administered systemically. Ten of these eyes (10%) developed a wound dehiscence requiring resuturing. The other group consisted of 1002 cataract operations where 20 mg of prednisone was administered subconjunctivally after the operation. No wound dehiscences occurred in this group. Pretreatment may be of value where fistual formation is desired, ie, with glaucoma surgery.