Gender-Based Cerebral Perfusion Differences in 46,034 Functional Neuroimaging Scans.

2017 
Abstract Studies have reported that females have widespread increases in regional cerebral blood flow, but the studies were relatively small and inconsistent. Here we analyzed a healthy and very large psychiatric population to determine the effect of gender, using single photon emission computed tomography (SPECT). Whole brain and region of interest (ROI) gender differences were analyzed in a total of 46,034 SPECT scans at baseline and concentration. The sample included 119 healthy subjects and 26,683 patients; a subset of 11,587 patients had complete diagnostic information. A total of 128 regions were analyzed according to the AAL Atlas, using ROI Extract and SPSS statistical software programs, controlling for age, diagnoses, and correcting for multiple comparisons. Compared to males, healthy females showed significant whole brain (p
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