BATCH FLUID BED GRANULATION
1997
INTRODUCTION
The size enlargement of primary particles has been carried out in the pharmaceutical industry
in a variety of ways. One of the most common unit operations used in the pharmaceutical
industry is the fluid-bed processing where the granules are produced in a single piece of
equipment by spraying a binder solution onto a fluidized powder bed. This process is
sometimes classified as the one-pot system because granulation and drying are carried out in
the same equipment. The batch fluid bed granulation process is a well-established unit
operation in the pharmaceutical industry; however, other process industries, such as food,
nutraceutical, agrochemical, dyestuffs, and other chemical industries, have adopted fluid-bed
granulation process to address particle agglomeration, dust containment, ease of material
handling, and modifying particle properties to provide dispersibility or solubility to products,
among other product enhancements.
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