Association between CD40 rs1883832 and immune-related diseases susceptibility: A meta-analysis

// Jiaxuan Qin 1, 2, 3 , Jinchun Xing 1, 2, 3 , Rongfu Liu 1, 2, 3 , Bin Chen 1, 2, 3 , Yuedong Chen 1, 2, 3 and Xuan Zhuang 1, 2, 3 1 Department of Urology Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China 2 Center of Diagnosis and Treatment of Urinary System Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China 3 The Key Laboratory of Urinary Tract Tumors and Calculi, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China Correspondence to: Jinchun Xing, email: jinchun_xing@163.com Keywords: CD40, rs1883832, immune-related disease, meta-analysis, SNP Received: May 17, 2017      Accepted: June 17, 2017      Published: June 28, 2017 ABSTRACT Background/objective: It has been reported that CD40 rs1883832 might be associated with immune-related diseases susceptibility. Owing to mixed and inconclusive results, we conducted a meta-analysis of case–control studies to summarize and clarify this association. Methods/main results: A systematic search of studies on the association between CD40 rs1883832 and immune-related diseases susceptibility was conducted in databases. Odds ratios and 95% confidence intervals were used to pool the effect size. 40 articles were included in our meta-analysis. Conclusions: CD40 rs1883832 is associated with decreased risk of Graves’ disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto’s thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behcet's disease (BD), myasthenia gravis (MG), Crohn’s disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP).