GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment

Jianlong Li,Jinquan Cai,Shihong Zhao,Kun Yao,Ying Sun,Yongli Li,Lingchao Chen,Ruiyan Li,Xiuwei Zhai,Junhe Zhang,Chuanlu Jiang

GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment

2016

Jianlong Li
Jinquan Cai
Shihong Zhao
Kun Yao
Ying Sun
Yongli Li
Lingchao Chen
Ruiyan Li
Xiuwei Zhai
Junhe Zhang
Chuanlu Jiang

Background The aim of this study was to investigate the effect of downregulating Hedgehog pathway by GANT61 on human glioma cells, examine the consequent changes of temozolomide (TMZ)-induced effects and explore the molecular mechanisms.

Keywords:

Cancer research
Temozolomide
Hedgehog
Biology
Hedgehog signaling pathway
Molecular biology
Glioma
Apoptosis
Cell culture
GLI1
Comet assay
Cell
DNA damage

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