Reduced nociceptive responses in mice with alloxan induced hyperglycemia after garlic (Allium sativum Linn.) treatment

Administrat,on of ethanol (95%) extract (45 mglkg body wt/day for 28 days) of garlic (A . sali vlI/Il) to alloxan induced diabetic (A LX-D) mice significantly lowered (he serum glucose levels, nociceptive response in tail-fli ck, hotplate, allodynia, formalin test and relative thickness, weight of hind paw in formalin induced Paw oedema test , over 28 days, thus, showing the reversa l trend in hy perglycemia and hyperalgesia compared to ALX-D mice. The reversal of hyperglycemia and hyperalgesia was progressive and more effective as duration of extract administration increased. The results suggest therapeutic potential of ethanol extract of garlic for anti- hyperg lycemic and anti-nocicept ive effects in diabetes.