The CIS/SOCS proteins: a family of cytokine-inducible regulators of signaling.

INTRODUCTION: NEGATIVE REGULATION OF CYTOKINE SIGNALING Characterization of the signal transduction pathways activated by cytokine receptors has been a topic of intensive study for the last years. Although receptors belonging to the superfamily of cytokine receptors are devoid of tyrosine kinase activity, binding of their cognate ligands induces the tyrosine phosphorylation of several cellular proteins. The intracellular [...]