Relative dominance of epitope-specific CD8+ T cell responses in an F1 hybrid mouse model of respiratory syncytial virus infection

Abstract CD8+ cytotoxic T lymphocytes are key effectors of adaptive immunity for the control of virus infections. Epitope-specific responses are hierarchical and the rules for dominance are not well defined. Here we show that the H2-K d -restricted RSV M2 82–90 (K d M2 82–90 ) epitope dominates the H2-D b -restricted RSV M 187–195 (D b M 187–195 ) epitope and influences epitope-specific effector function in the acute and memory phases of the immune response to primary RSV infection in H-2 b/d hybrid mice. The hybrid mouse model provides a system to define rules of epitope hierarchy and better understand how antigen presentation and epitope competition affect the phenotype of effector and memory T cells.