One-step synthesis method of nitazoxanid

The invention relates to the field of chemical synthesis of medicines, and particularly relates to a synthesis method of amide type anti-anaerobe medicine nitazoxanid. The synthesis method is characterized by comprising the following step: by taking aspirin and 2-amino-5-nitrothiazole as raw materials, performing one-step amidation reaction to synthesize nitrothiazole. According to the method for preparing the nitrothiazole, the operation is easy, the required equipment is simple, the pollution is less, the raw materials are all easily available, the cost is low, the yield is high, and the conversion rate is 58.2%.