The composition and preparation method b ginkgolides in high purity active ingredient
2013
The present invention relates to a high purity ginkgolide B as the active ingredient composition, the composition is injection ginkgolide B, in parts by weight, the ginkgolide B Injection pharmaceutically active ingredient comprising: extract of ginkgolide B, 20 parts of polyethylene glycol -400580-630 parts, parts 770-830 and 640-700 parts ethanol, glycerol; ginkgolide B the extract obtained from ginkgo leaf extract, a ginkgo ester B extract contains ginkgolide B and K ginkgolides, ginkgolide B content of greater than 99%, the content of ginkgolide K is less than 0.6%. Ginkgolide B composition of the present invention is provided, as ginkgolide B drug substance extract high purity of ginkgolide B, ginkgolide K content is very low, to meet the requirements of the injection of the drug, improved the bioavailability, and patient medication safety of the drug substance.
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