ELEVATED GENTAMICIN LEVELS IN PREMATURE/AZOTEMIC NEWBORNS

Peak serum gentamicin (G) levels were measured by agar diffusion 30 minutes after completion of, and trough levels just prior to, intravenous G infusion (2.4±.1mg/kg) in 44 neonates aged 14 days or less ( 5.5 days). Gestational ages (GA) ranged from 26-43 weeks ( 34.4±.7 wks). Serum half-lives (T½), peaks, and troughs (±SEM) in 23 non-azotemic infants [BUN<15mg% and/or Creatinine (Cr)<1mg%] are presented below: