Peculiar features of immunogenetic parameters in children with atopic diseases

Aim . To determine the peculiarities of distributing antigens of major histocompatibility complex in children with atopic dermatitis and children with bronchial asthma. Materials and methods . Serologic typing of HLA class I-complex antigens and molecular typing of HLA class II-complex antigens was fulfilled in 52 children (age range 5 to 14 years) with disseminated moderate and severe atopic dermatitis and 122 children (age range 5 to 14 years) with moderate and severe atopic bronchial asthma. Results . Among children with atopic dermatitis, there was found high incidence rate of HLA-complex antigens B15, B16, B17, DRB1*13 and DQB1*0602-8, presentation of which was associated with elevation of relative risk for the development of disease by 3.3–8.4 times. In children with atopic bronchial asthma, the observed high incidence rate of HLA-complex antigens A26, B18 and DRB1*17 was associated with rise of relative risk for the development of disease by 3.0–9.1 times.