Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases

Brian S. Gerstenberger,Catherine M. Ambler,Eric P. Arnold,Mary Ellen Banker,Matthew Frank Brown,James D. Clark,Alpay Dermenci,Martin E. Dowty,Andrew Fensome,Susan Fish,Matthew Merrill Hayward,Martin Hegen,Brett D Holingshead,John D. Knafels,David W. Lin,Tsung H. Lin,Dafydd R. Owen,Eddine Saiah,Raman Sharma,Felix F. Vajdos,Li Xing,Xiaojing Helen Yang,Xin Yang,Stephen W. Wright

Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases

2020

Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family that regulates signal transduction downstream of receptors for the IL-23/IL-12 pathways and type I interferon family, where it pairs wi...

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Chemistry
Cancer research
Tyrosine kinase 2

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