Mutagen and Oncogen Study o Octylphenyl-alpha-Naphthylamine

Abstract : The material evaluated in this study was subjected to a matrix of in vitro assays employing microbial cells, mammalian cells in culture and in vivo tests measuring potential germ cell effects in mice and rats. Octylphenyl-alpha- Naphthylamine appeared to have little or no genotoxic properties. The only evidence for possible DNA interaction was obtained in tests for UDS in WI-38 cells. Microbial and mouse cell culture tests for gene mutation were negative as were dominant lethal assays in both mice and rats. The potential for carcinogenic activity by the test compound was considered negative as a result of this battery of tests.