Quinoline and quinazoline derivatives, the preparation method, intermediates, compositions and Applications

The present invention discloses quinoline and quinazoline derivatives I, preparation, Intermediate C, and application of the composition. The preparation method comprises: Method a: ① a solvent, under the action of a base 1, Compound A is reacted with compound B, to give compound C; ② a solvent, under the action of a base 2, a step ① the product obtained in C with a compound D; method II: a solvent, a base 1 under the action of compound a is reacted with compound E. The present invention further provides a compound of Formula I or pharmaceutical compositions described above for the preparation of EGFR tyrosine kinase inhibitor, cell proliferation inhibitor of A431 or H1975, prophylactic or therapeutic medicament or tumor diseases. The present invention provides compounds having a better antitumor activity. .