P135 : Periodontitis and risk for psoriasis: A nationwide cohort study

Background: Periodontitis is a chronic inflammatory disorder involving the periodontium. The precise nature of the association between periodontitis and psoriasis and its underlying mechanism have not been determined. Objectives: This nationwide population-based study investigated the relationship between periodontitis and risk for psoriasis. Methods: A health screening database, which is a sub-dataset of the Korean National Health Insurance Service database, was used in this study. Patients (≥20 years old) who underwent health screening from January 2009 to December 2009 were included. Results: We identified 1,063,004 patients with periodontitis and 8,655,587 patients without it. In multivariable analysis, compared to the non-periodontitis group, patients with periodontitis had a significantly higher risk of developing psoriasis (hazard ratio, 1.116; 95% confidence interval, 1.101-1.13). Non-smokers with periodontitis exhibited an 11% increase in risk for psoriasis and smokers with periodontitis exhibited a 26.5% increase in the risk for psoriasis copmpared to non-smokers without periodontitis. Diagnosis of periodontitis and psoriasis were made according to diagnostic codes without a detailed review of medical charts. Conclusion: Our study highlights periodontitis as a potential independent risk factor for psoriasis, increasing awareness of the role of periodontitis in the pathogenesis and comorbidities of psoriasis.