Synthesis, spectral studies, XRD, thermal investigation and biological screening of metal complexes derived from (N-(3-methoxyphenyl)-2-[(2E)-3-phenylprop-2-enoyl] hydrazinecarboxamide

A series of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) metal complexes are derived from ligand (N-(3-methoxyphenyl)-2-[(2E)-3-phenylprop-2-enoyl]hydrazinecarboxamide[MPH], and structurally characterized by various physicochemical and spectral tools such as IR, UV-Visible, 1 H-NMR, LC-Mass, powder XRD and TGA-DTC.These studies showed that the ligand coordinated to the metal atom in a bidentate manner and have octahedral environment.X-ray diffraction studies indicates that the Co(II) and Cu(II) complexes are Crystalline in nature, Degradation mechanism, kinetic and thermodynamic parameters of the synthesized metal complexes has been evaluated.The synthesized compounds were evaluated for in vitro antioxidant DPPH assay, in which metal complexes showed excellent activity. The molecular docking analysis by using human antioxidant enzyme DTT (PDB: 3MNG) have also been evaluated. The ligand and their metal complexes were screened for their antifungal and antibacterial activities against different species of pathogenic fungi and bacteria.