Randomized double-blind comparison of gallopamil and propranolol in stable angina pectoris

Abstract A new calcium ion antagonist, gallopamil, 150 mg/day, was compared with propranolol, 240 mg/day, in 20 patients with stable chronic angina. The patients were studied in a randomized, placebo-controlled, double-blind, crossover trial. Multistage treadmill exercise with computer-assisted electrocardiographic analysis was performed after 2 weeks of placebo therapy and at the end of each 4-week active treatment period. The mean ( ± standard error of the mean) exercise time to development of angina was 5.4 ± 0.3 minutes with placebo; this increased to 9.4 ± 0.7 minutes with propranolol (p