Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

Dongjun Peng,Ilona Kryczek,Nisha Nagarsheth,Lili Zhao,Shuang Wei,Weimin Wang,Yuqing Sun,Ende Zhao,Linda Vatan,Wojciech Szeliga,Jan Kotarski,Tarkowski R,Yali Dou,Kathleen R. Cho,Sharon Hensley-Alford,Adnan R. Munkarah,Rebecca Liu,Weiping Zou

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

2015

Dongjun Peng
Ilona Kryczek
Nisha Nagarsheth
Lili Zhao
Shuang Wei
Weimin Wang
Yuqing Sun
Ende Zhao
Linda Vatan
Wojciech Szeliga
Jan Kotarski
Tarkowski R
Yali Dou
Kathleen R. Cho
Sharon Hensley-Alford
Adnan R. Munkarah
Rebecca Liu
Weiping Zou

Treating ovarian cancer in mouse models with inhibitors for the epigenetic regulators EZH2 and DNMT1 increases the expression of the inflammatory chemokines CXCL9 and CXCL10, resulting in enhanced tumour infiltration by effector T cells, and slowed tumour progression.

Keywords:

Tumor Escape
Ovarian cancer
Immunotherapy
Gene silencing
Cancer
Cancer research
Immunology
Cancer epigenetics
Epigenetics
Biology
Effector
Reprogramming
DNA methylation
EZH2

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