Lack of association of angiotensin-converting enzyme insertion/deletion polymorphism with breast cancer: An update meta-analysis based on 10405 subjects

Objective: Previous case-control studies on the relation between angiotensin-converting enzyme (ACE) gene insertion/ deletion (I/D) polymorphism and breast cancer did not reach the same conclusion. In the present study, we aimed to further evaluate the relationship between the ACE gene I/D polymorphism and breast cancer. Methods: We selected 13 case-control studies related to ACE gene I/D polymorphism and breast cancer by searching PubMed, EMBase, Chinese Biomedical Literature Database, Chinese CNKI, and Wanfang database. To test the heterogeneity between each study, we utilized the Q-test and I 2 test. To merge the odds ratio (OR) and 95% confidence interval (CI), we utilized the random effects model during the analyses. Results: The present study included 1997 patients with breast cancer and 8404 cancer-free control subjects. By metaanalysis, we did not find any association of ACE gene I/D polymorphism with breast cancer in different model (DD vs (ID+II): OR=1.28, 95% CI (0.90–1.81), p=0.16; II vs (ID+DD): OR=0.99, 95% CI (0.81–1.21), p=0.93; D allele vs I allele: OR=1.15, 95% CI (0.94–1.41), p=0.18). Conclusion: We concluded that ACE gene I/D polymorphism was not associated with breast cancer.