Process for preparation of gemcitabine and associated intermediate compound.
2007
Process for preparing gemcitabine and associated intermediates. The present invention provides novel intermediate steps, preferably including derivatives of 2,2-difluoro-3-hydroxy-3- (2,2-dialquildioxolan-4-yl) -propionate alkyl substituted in position 3, and derivatives of 2-deoxy-2,2-difluoro-1-oxo-D-ribose disubstituted 3.5. The present invention also provides processes for producing such intermediate steps and processes for producing gemcitabine therefrom.
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