A highly effective one-pot synthesis of quinolines from o -nitroarylcarbaldehydes
2007
A highly effective one-pot Friedlander quinoline synthesis using inexpensive reagents has been developed. o-Nitroarylcarbaldehydes were reduced to o-aminoarylcarbaldehydes with iron in the presence of catalytic HCl (aq.) and subsequently condensed in situ with aldehydes or ketones to form mono- or di-substituted quinolines in high yields (66–100%).
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