Studies of the Effect of Perthane on Spontaneous and Transplanted Mammary Carcinoma in the C3H Mouse

Summary 1.Perthane, fed to C3H unbred female mice in a maximum tolerated dosage for life, prevented the formation of spontaneous mammary carcinoma in all animals treated. 2.No direct anti-tumor effect could be demonstrated in studies of transplanted mammary carcinoma in the C3H mouse. 3.Decreased ovarian size, depressed corpus luteum activity, as well as uterine and vaginal epithelial atrophy occurred in animals treated for long periods. No evidence of adrenal cortical hypoplasia or hyperplasia could be demonstrated histologically in animals receiving Perthane in our experiments. 4.Possible mechanisms of the action of Perthane are discussed.