Preparation method of piperazine phosphate

The invention relates to a preparation method of piperazine phosphate. The method includes: fully dissolving phosphoric acid and anhydrous piperazine in an organic solvent, and conducting filtering, salifying the two substances in a reaction kettle under suitable reaction conditions, and after complete reaction, carrying out cooling crystallization, centrifugation, washing, and vacuum drying, thus obtaining the piperazine phosphate. The method provided by the invention employs fewer organic solvent, achieves a yield up to over 90%, the product has high purity, also the process is simple, the operation is easy, the cost is greatly lowered, and the method is easy for industrial production. The piperazine phosphate provided by the invention is often used for treating children's ascaris and pinworm infection.