Pharmacokinetics of cefepime in patients with the sepsis syndrome

We investigated the pharmacokinetics of cefepime after administration of multiple doses to seven patients with the sepsis syndrome. Patients ranged in age from 66 to 78 years (mean±S.D.:74± 5 years); all fulfilled the criteria of the sepsis syndrome and had APACHE-II scores between 14 and 21 (mean±S.D.:17±2). Serial blood and urine samples were collected after a minimum of 3 days (steady state) of treatment with cefepime 2.0 g bd iv. Cefepime was assayed by HPLC. Data were analysed using non-compartmental methods. The mean±S.D. creatinine clearance (Cl cr ) was 55±8 mL/min