Clinical Contrast Study of Botulinum Toxin Type A Injection Treating Hemifacial Spasm

Objective:To contrastlly investigate the efficacy and safety of BTX-A injections(BI) and purely orally drug treatment(PDT) for hemifacial spasm.Methods: Clinical efficacy was evaluated by observing average on-effect time(AET),average efficacy duration(AED),side-effects incidence rate(SIR),average side-effects duration(ASD),average treatment frequency(ATF) per year,average treatment cost(ATC) per year,excellence rate(ER) and total effective rate(TER),after 100 patients with hemifacial spasm treated with BI and 40 patients with PDT.Results: There were obviously differences between BI group and PDT group in AET(respectively 3.4±1.4 days and 12.6±3.9 days),AED(respectively 169.5±46.3 days and 6.8±2.8 days),SIR(respectively 28.6% and 68.2%),ASD(respectively 16.5±5.7 days and 6.3±1.1 days),ATF(respectively 2.6±0.7 days and 292.6±80.4 days),ATC(respectively 972.4±67.4 yuan and 1873.3±547.6 yuan),ER(respectively 94.3% and 34.1%),and TER(respectively100.0% and 59.1%))(all P0.01).Conclusions: Because of high ER,fine safety and low ATC,BTX-A injection has obvious advantage on purely orally drug treatment and is the first choice for hemifacial spasm.