Detection of oral cancerous cells using highly sensitive one-dimensional distributed Bragg’s Reflector Fabry Perot Microcavity

Abstract In the proposed work, a multi-layered Distributed Bragg’s Reflector (DBR) Fabry Perot Microcavity resonator is proposed theoretically to sense bio-analyte. One dimensional Photonic-Crystal (PhC) sensor is designed and analysed to sense the presence of oral cancerous cells in the analyte. The Characteristic Matrix Method (CMM) is used to design, model and analyse the proposed sensor. A multi-layer structure with a central defect having 3 pairs of high and low refractive index layers on either side of the defect is analysed for its sensing performance. The incident light having wavelength in the range of mid-infrared frequency is used at input source, which enhances the sensor sensitivity. Five normal (INOK) cells and oral cancerous (YD-10B) cells are considered for the analysis of sensor performance. The effect of variation in the geometrical length of central defect layer and the number DBR layers on resonant wavelength, sensitivity, and Q factor is performed. A highest sensitivity of 3630 nm/RIU with a Q-factor of 11,323 and a very minimum resolution of 9.5 × 10−5 RIU is obtained. The sensor proposed in this work is suitable for label-free, easy fabrication, cost-effective, and highly sensitive sensor designs for biomedical applications.