Self-assembling short peptides capable of repairing uterus and protecting cardiac muscle and application thereof

2015 
The invention discloses self-assembling short peptides capable of repairing the uterus and protecting the cardiac muscle. The self-assembling short peptides are divided into three short peptides, and the amino acid sequences respectively comprise GFS-4: Arg Leu Glu Cys Lys Ala Asp Ala Arg Leu Glu Cys Lys Ala Asp Ala; GFS-5: Arg Leu Glu Cys Lys Ala Asp Ala Arg Leu Glu Val Lys Ala Asp Ala; and GFS-6: Ala Asp Ala Lys Val Glu Leu Arg Ala Asp Ala Lys Cys Glu Leu Arg, wherein all the amino acids in the GFS-6 refer to D type amino acids, and the carbon terminals of the short peptides are amidated. According to the short peptides disclosed by the invention, three-dimensional cell culture can be supported, and a three-dimensional environment of an extracellular matrix can be simulated in vitro by virtue of the formed nanofibers and is used for three-dimensional culture of animal cells and vegetable cells. In addition, the self-assembling short peptides can serve as materials for repairing the uterus and protecting the cardiac muscle.
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