Detrusor dynamics. I. Effect of prostaglandin f2 alpha on tension-length relationship.

We used 50 detrusor strips to evaluate the possible modulatory effect of prostaglandin F2 alpha on the dynamics of bladder wall during stretch. Prostaglandin F2 alpha showed a positive excitatory effect on the total mural tension in doses up to 2 micrograms per ml within muscle lengths up to 140 per cent of the equilibrium length. At higher doses and greater lengths a mild inhibitory effect was evident. In contrast, the excitatory effect of urecholine continued up to double the equilibrium length.