Soluble interleukin-6 receptor and autoantibodies in serum of children Tourette's syndrome

Objective The purpose of our study was to investigate the presence of autoantibodies and soluble IL-6 receptor in patients with Tourtte's syndrome.explore the mechanism underlying the immunologic regulation with IL-6 receptor.Methods The serum contents of anti-brain antibody(ABAb),antinuclear antibody(ANAb),soluble IL-6 receptor(sIL-6R),and soluble gp130(sgp130)in 67 patients and 64 health indivadual were analyzed with commercialized ELISA kits,and examined the titer of antistreptolysin O in TS and control with Iatex enhanced immunoturbidimetry.Results The Ievels of sIL-6R and sgp130 were significantly elevated in TS compared with control group(44±16)pg/L NS.(30±9)pg/L,P=0.000,P＜0.01;(69±25)pg/L NS.(47 ±14)pg/L,P=0.000,P＜0.01,respectively.The detection rate of anti-brain antibody,antinuclear antibody in TS were more than that in control group(67% NS.3%,P=0.000 P＜0.01;53%NS.25%,P=O.001,P＜0.01).Increases ASO titer(＞250 kU/L)were found in a higher portion with TS(20%)compared to control(0%).The level of ABAb was inversely correlated with sgp 130 concentration(r=-0.375,P＜0.05).Conclusion The expression of IL-6 receptor and autoantibodies are abnormal in children Tourette's syndrome,which suggested that the central nerous tissue autoimmune-related immunologic injuries may be involved in the pathogenesis of the disease development. Key words: Tourette's syndrome;  Autoantibodies;  Receptors,interleukin-6;  Cytokine receptor sgp