Benchmarking Outcomes for Definitive Treatment of Young-Onset, Locally Advanced Rectal Cancer

Abstract Purpose There has been an increase in the incidence of rectal cancer diagnosed in young adults (age Methods The medical records of 219 patients, age 18-49, with non-metastatic, cT3-4, or cN1-2 rectal adenocarcinoma treated from 2000-2017 were reviewed for demographic and treatment characteristics, as well as pathologic and oncologic outcomes. Kaplan-Meier test, log-rank test, and Cox regression analysis were used to evaluate survival outcomes. Results The median age at diagnosis was 44 years. CRT followed by TME and post-operative chemotherapy was the most frequent treatment sequence (n=196), with FOLFOX (n=115) as the predominant adjuvant chemotherapy. There was no difference in sex, stage, MSS/pMMR, or pCR by age ( Conclusion Among young adults, patients with age Micro Abstract: Among young adult patients treated with long course chemoradiation and surgery, patients with age