Acute renal insufficiency caused by oral everolimus in one patient with advanced kidney cancer

Objective: To explore the cause of acute renal insufficiency induced by oral everolimus in one patient with advanced kidney cancer.Methods: The clinical records of one advanced kidney cancer patient developing acute renal insufficiency after oral administration of everolimus and anti-infective drugs were analyzed. The renal function was observed after continuous renal replacement therapy.Results: Acute renal insufficiency occurred after treatment with everolimus for four days, while pulmonary infection was likely to get better after anti-infective treatment. There were no relevant reports about the adverse effects of anti-infective drugs, which the patient used, on the function of the kidney. There were some reports regarding the acute renal insufficiency caused by everolimus. As an inhibitor of cytochrome P450 (CYP450), fluconazole may aggravate the renal insufficiency by inhibiting the metabolism of everolimus.Conclusion: Combination of CYP450 inhibitor and everolimus may increase the incidence of adverse reactions of everolimus, and the acute renal insufficiency caused by everolimus could be cured by continuous renal replacement therapy. DOI:10.3781/j.issn.1000-7431.2015.66.730