[The expressional alterations of CSF-1R after ischemic injury of cerebral cortex].

Aim: To observe the expressional alterations of colony stimulating factor-1 receptor(CSF-1R) after ischemic injury of cerebral cortex,and study the function of colony stimulating factor-1(CSF-1)/CSF-1R signal during the process of ischemic injury and repair of central nervous system (CNS).Methods: We examined the distribution and expression of CSF-1R in normal brain tissues and ischemic brain tissues by immunohistology and Western blot analysis.Results: The expression of CSF-1R in neurons could be up-regulated by ischemic injury in CNS.Conclusion: CSF-1/CSF-1R might take part in the process of ischemic injury and repair.