Synthesis of Novel Pyridotriazepinones as Antisecretory Agents
1987
In connection with the known antisecretory activity of the benzotriazepinone (1) and the pyridylurea (2), novel pyridotriazepinones (3 and 4) have been synthesized. They were prepared from aminopyridinecarboxylic acids via several steps, and their structures were confirmed by X-ray crystallographic analysis. Attempts to synthesize the positional isomer (24) resulted in formation of the pyridotriazine (25 or 26). Some of these compounds showed moderate antisecretory activity in rats.
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