Study on reproductive performance for hairless mice of inbred strain

Aim:To study the reproductive performance for hairless mice of inbred strain and find out the best way to keep this mutant strain. Methods: The 4 different mating patterns were adopted. The average fetus number, average whelp number, average weaning rate had been investigated from 21 to 29 generations. Results:For forced crossing of heterozygous hairy males and females or forced crossing homozygous hairy males and females,there was significant difference in average hairless fetus number but not in average whelp number or average weaning rate . If forced crossing of hairless males and hairless females or heterozygous males and hairless females, the females were difficult to be pregnant and even if pregnant,all the born babies would die before weaning day.Conclusion: The best way to keep this mutant hairless strain should be forced crossing between homozygous hairless males and heterozygous females inbred.