G-CSF産生下咽頭Spindle Cell Carcinoma例

This is the case report of a 69-year-old man with a spindle cell carcinoma of the hypopharynx which produced G-CSF. Clinically, the tumor showed resistance to chemotherapy, while the patient was suffering from high fever and leukocytosis despite no evidence of infection. Moreover, the tumor exhibited rapid growth. Microscopic examination revealed, a spindle cell carcinoma which had developed from a squamous cell carcinoma, and which had a bizarre appearance reminiscent of malignant fibrous histiocytosis. The tumor cells of the squamous cell carcinoma and spindle cell carcinoma were immunohistochemically stained with monoclonal anti-G-CSF antibodies. This is the first case of a G-CSF-producing spindle cell carcinoma of the hypopharynx to be reported in Japan.