Development of a Model-Based Quality-by-Control Framework for Crystallization Design

Abstract The work proposes a combination of model-free and model-based quality-by-control (mfQbC and mbQbC) paradigms as a general framework for the optimal crystallization design with the aim of minimization of fines and agglomerates in the product. This framework provides an improved alternative to the current industrial practice, by the combined use of feedback control and mathematical models for rapid design of robust crystallization processes. The implementation of the proposed mbQbC framework enhanced the prediction of crystallization events and was able to achieve better control of the crystallization processes by providing controlled heating/cooling cycles, for deagglomeration and fines destruction. The information for parameter estimation and optimization calculations was collected from the experiments in mfQbC part, which additionally also provided a rapid design of robust operating conditions, which subsequently in the mbQbC approach were improved to achieve optimal operation.