REACTION OF 1,2,3,4-TETRAHYDRO-2,4,5-TRIMETHYLPYRROLO[1,2- c ]PYRIMIDINE AND ITS 7-FORMYL-SUBSTITUTED DERIVATIVE WITH NITRIC ACID

1,2,3,4-Tetrahydro-2,4,5-trimethylpyrrolo[1,2-c]pyrimidine and its 7-formyl derivative when treated with nitric acid are converted to substituted tetrahydropyrrolo-[1,2-c]pyrimidine-7-carboxylic acid. Conversion occurs through opening of the aminal moiety and formylation of the second molecule of tetrahydropyrrolo[1,2-c]pyrimidine by formaldehyde formed to the 7-formyl-substituted derivative. Authors: A. V. Varlamov, T. N. Borisova, E. A. Sorokina, and A. I. Chernyshev. English Translation in Chemistry of Heterocyclic Compounds , 1999, 35 (2), pp 195-198 http://link.springer.com/article/10.1007/BF02251708