Long-term effects of radiotherapy for acromegaly on circulating prolactin

In 61 acromegalic patients, serum PRL was assessed before and 2 to 12 years after external beam radiotherapy. No correlation was found between pretreatment PRL values and final GH values in the whole group, nor between changes in PRL and the development of impaired ACTH or TSH secretion. These changes do not predict final GH results or the development of hypopituitarism after radiotherapy