Infarct size limitation by gene transfer of baculoviral p35 into rat myocardium

The fate and effect of engrafting fetal cells into infarcted hearts remains unclear. One approach to overcoming this limita- tion is to graft a naturally modified extrecellular matrix (collagen-1) scaffold onto the myo- cardium. We found, three-weeks after grafting, the 3-D collagen scaffold was integrated completely with the cryo-injured myocardium. The scaffold prevented LV dilation. At zero left ventricular (LV) pressure, the LV lumen diameter and the outer