The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD

In this study, the authors show that the mouse ortholog of the amyotropic lateral sclerosis/frontotemporal dementia (ALS/FTD)-associated human locus C9ORF72 exhibits highly enriched expression in the neuronal cell types that show susceptibility during the disease. These findings suggest a potential explanation for the cell selectivity observed in ALS/FTD.