Preparation and Evaluation of Stable Nonionic Surfactant Vesicular System for Tramadol HCl

The study was aimed at developing and optimizing a stable nonionic surfactant vesicular system known as niosomes for Tramadol HCl in order to improve its release properties and bioavailability. In the study different composition of non ionic surfactants and lipids were used to prepare nonionic surfactant vesicles formulation. The formulations were evaluated for entrapment efficiency, particle size, zeta potential, viscosity and in vitro drug release in 12 hrs. The in vitro permeability of the drug was evaluated by using dialysis membrane. The results of the in vitro drug release / permeability in 12 hrs shows better release in comparison with pure drug and marketed