CK2|[alpha]| phosphorylates BMAL1 to regulate the mammalian clock

BMAL1 has a central role in the mammalian circadian clock, acting as a transcriptional activator. The activity of BMAL1 is controlled by post-translational modifications such as acetylation and SUMOylation. Now the kinase CK2a is shown to phosphorylate BMAL1 at Ser90, and this is essential for BMAL1's function in the circadian clock.