INDORAMIN: 24 HOUR PROFILE OF INTRA-ARTERIAL AMBULATORY BLOOD PRESSURE, A DOUBLE-BLIND PLACEBOCONTROLLED CROSSOVER STUDY

Abstract 1 Indoramin is a new α-adrenoceptor blocking agent. We have evaluated the profile of blood pressure reduction over 24 h with intra-arterial ambulatory blood pressure monitoring by means of a double-blind placebo-controlled crossover trial. The effect on the heart rate was also recorded. 2 The blood pressure response to standardized procedures including supine rest, tilt, isometric and dynamic bicycle exercise were also recorded. 3 Indoramin caused a significant reduction of the ambulatory blood pressure during 16 h of the day for systolic pressures and 12 h for diastolic pressures. 4 There was no evidence of postural hypotension or sustained reflex tachycardia. The absolute blood pressures were lowered during isometric and dynamic exercise. 5 Indoramin was associated with a high incidence of side-effects; however if used in combination with other antihypertensive agents a lower dose might well be better tolerated.