Antiretroviral therapy outcomes of HIV-infected children in the TREAT Asia pediatric HIV observational database.

INTRODUCTION: We report responses to combination antiretroviral therapy (cART) in the Therapeutics Research Education and AIDS Training in Asia Pediatric HIV Observational Database. METHODS: Children included were those who had received cART (ie >/=3 antiretrovirals) at /=25% within 5 years were more likely to be females (HR: 1.4; 1.2-1.7) start before 18 months old (HR: 3.8; 2.4-6.2) lack a history of monotherapy/dual therapy (HR: 1.7; 1.4-2.5) and have a higher baseline CD4 (per 10% increase: HR: 2; 1.9-2.2). CONCLUSIONS: These data underscore the need for early diagnosis and cART initiation to preserve immune function.